Your doctor can tell you if Nicorette gum will interact with any medication that you are taking. If you are taking prescription medicine then your doctor may advise you to alter the dosage once you begin using Nicorette gum. This because once you stop smoking you can increase the blood levels of medications like the asthma medication theophylline or the antidepressant imipramine, or decrease the absorption rate of others like glutethimide. Although Nicorette gum is sugar-free, the dosage of insulin taken by someone using Nicorette gum may need to be altered because it will be absorbed at a faster rate once you stop smoking.

If you have dental caps or dental bridgework, you should consult with your dentist before using Nicorette gum because it may damage dental work by sticking to it. Nicorette gum is not recommended for those with dentures.

Possible side effects to using Nicorette gum, all of which should be temporary, may appear in the early stages of treatment. These include ulceration or soreness of the mouth or throat, skin rashes or redness, and a slight, generalized ache in the jaw caused by chewing the gum. Consult your doctor if any of these conditions persist.